Anti-PR3 (PR3-ANCA) antibodies, quantitative (ICL)
The test quantitatively determines antibodies to proteinase-3 (PR3-ANCA) — autoantibodies characteristic of ANCA-associated vasculitis, primarily granulomatosis with polyangiitis. Used for diagnosis, disease activity assessment, and therapy efficacy monitoring.
Biomaterial: Venous blood
- Draw blood fasting 8-12 hours (no water);
- exclude alcohol 24 hours before;
- avoid stress and physical activity 30 minutes before.
- Inform physician of immunomodulator, hormonal, or anti-inflammatory drug intake.
- Suspected systemic vasculitis;
- chronic ENT organ and/or lung inflammations;
- kidney involvement (protein, blood in urine);
- skin rashes, ulcers, hemorrhages;
- prolonged fever of unclear origin;
- previously diagnosed vasculitis activity monitoring.
Negative — anti-PR3 antibodies not detected.
Positive — anti-PR3 antibodies detected; characteristic of granulomatosis with polyangiitis and other ANCA-associated vasculitis.
Note: Results evaluated only together with clinical picture and other studies (ANCA, MPO, CRP, urine tests).
