Anti-Sm IgG antibodies, quantitative (ICL)
Detects antibodies to Sm protein for SLE diagnosis and activity monitoring.
Deviation mechanism: antibodies to Sm → immune complexes → inflammation, especially kidneys and joints.
Biomaterial: Venous blood
- Draw blood fasting (8-12 hours without food)
- Exclude alcohol 24 hours before
- Avoid stress and physical activity 30 minutes before
- Suspected SLE;
- joint pain, skin rashes, elevated temperature;
- elevated ESR/CRP;
- kidney involvement;
- SLE activity monitoring.
Negative — anti-Sm antibodies not detected.
Positive — anti-Sm detected; characteristic of SLE.
Rheumatologist consultation recommended.
