Celiac Disease Diagnostics: Endomysial Antibody Determination IgA, IgG, IIF, Titer — Gliadin Antibody Determination IgA/IgG and Tissue Transglutaminase IgA/IgG, ICL
The test detects antibodies to endomysium, gliadin, and transglutaminase (IgA and IgG), used for diagnosing celiac disease, assessing disease severity, and monitoring gluten-free diet adherence.
Composition (antibodies in celiac disease diagnostics):
Endomysial antibodies:
IgA (EMA IgA, IIF)
IgG (EMA IgG, IIF) — marker of autoimmune damage to the small intestine mucosa
Gliadin antibodies:
IgA (Gliadin IgA, ELISA/ICL)
IgG (Gliadin IgG, ELISA/ICL) — immune system reaction to gluten proteins
Transglutaminase antibodies:
IgA (tTG IgA, ELISA/ICL)
IgG (tTG IgG, ELISA/ICL) — marker of small intestine damage and autoimmune reaction in celiac disease
Biomaterial: Venous blood
- Submit fasting (8-12 hours without food)
- Avoid alcohol for 24 hours
- Avoid stress and physical exertion 30 minutes before
- Inform the doctor if taking immunomodulators, hormonal, or anti-inflammatory medications.
- suspected celiac disease
- chronic diarrhea or constipation of unknown origin
- weight loss, anemia, or vitamin deficiency
- nutrient malabsorption
- monitoring gluten-free diet adherence in already diagnosed patients
Negative result — antibodies not detected
Positive result — antibodies to endomysium, gliadin, or transglutaminase detected, characteristic of celiac disease or increased risk of its development
Important: the result is assessed together with clinical data and other laboratory tests; small intestine biopsy is sometimes required
