Dehydroepiandrosterone sulfate (DHEA-S) (Dehydroepiandrosterone Sulfate, DHEA-S, Serum)
The test determines the concentration of DHEA-S — the stable, biologically inert form of DHEA circulating in blood. DHEA-S is synthesized almost exclusively by the adrenal cortex, making it a reliable adrenal function marker. Used for precise assessment of adrenal androgenic activity. Helps differentiate hyperandrogenism source: adrenal or gonadal (ovaries/testes). Applied in PCOS, congenital adrenal hyperplasia, and adrenal tumor diagnosis.
What the test evaluates:
- DHEA-S level in blood serum
- Adrenal cortex secretory activity
- Adrenal androgenic contribution to hormonal status
Biomaterial: Venous blood
- Draw blood fasting
- Exclude physical activity and emotional stress 24 hours before
- Avoid smoking before blood draw
Medications:
- Hormonal drugs, glucocorticoids, and oral contraceptives may affect results
- Medication discontinuation only by physician agreement
Recommended for:
- Adrenal disease and hyperandrogenic condition diagnosis
- Menstrual irregularities, infertility, PCOS
- Hormonal disorders and reduced reproductive function in men
- Suspected adrenal tumors
Elevated DHEA-S: characteristic of adrenal hyperandrogenism, adrenal tumors, or cortex hyperplasia
Normal DHEA-S with elevated androgens: may indicate ovarian source
Reduced values: possible adrenal insufficiency and age-related changes.
