Diagnostics of Demyelinating CNS Diseases (Multiple Sclerosis, Neuromyelitis Optica): Aquaporin-4 Antibody Determination, IIF, Titer — Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Determination, IIF, Titer
The test detects antibodies to aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG). Used for diagnosing demyelinating diseases of the central nervous system, including neuromyelitis optica (Devic's disease) and MOG-associated diseases, as well as for differential diagnosis with multiple sclerosis.
Profile composition:
Aquaporin-4 (AQP4) antibodies, IIF, titer
Myelin oligodendrocyte glycoprotein (MOG) antibodies, IIF, titer
Biomaterial: Venous blood
- Submit fasting (8-12 hours without food)
- Avoid alcohol for 24 hours
- Avoid stress and physical exertion 30 minutes before
- If taking immunomodulators, hormonal, or anti-inflammatory medications — inform the doctor.
- suspected multiple sclerosis
- suspected neuromyelitis optica (Devic's disease)
- optic neuritis
- unexplained sensory disturbances
- limb weakness
- recurrent episodes of spinal cord inflammation
- clarifying the type of demyelinating disease
Negative result — antibodies not detected.
Positive result:
AQP4 antibodies — characteristic of neuromyelitis optica
MOG antibodies — characteristic of MOG-associated demyelinating diseases
Important: the result is assessed only in combination with clinical symptoms, MRI data, and other tests.
