Extended vasculitis diagnostics — ANCA IIFL (cANCA/pANCA) + PR3 + MPO + GBM
Profile detects autoantibodies associated with vascular wall inflammation (vasculitis). Used for vasculitis diagnosis, type clarification, and disease activity monitoring. Includes: ANCA (cANCA/pANCA) titer — general screening; PR3 (antibodies to proteinase-3) — characteristic of granulomatosis with polyangiitis; MPO (antibodies to myeloperoxidase) — in microscopic polyangiitis and eosinophilic granulomatosis; GBM (antibodies to glomerular basement membrane) — associated with Goodpasture's syndrome.
Biomaterial: Venous blood
- Draw blood fasting 8-12 hours (no water);
- exclude alcohol 24 hours before;
- avoid stress and physical activity 30 minutes before.
- Inform physician of immunomodulator, hormonal, or anti-inflammatory drug intake.
- Suspected systemic vasculitis;
- prolonged fever of unclear origin;
- joint and muscle pain;
- skin rashes, hemorrhages, ulcers;
- kidney involvement (protein or blood in urine);
- chronic ENT organ or lung inflammation;
- established vasculitis activity monitoring.
Negative — autoantibodies not detected.
Positive — antibodies characteristic of systemic vasculitis or Goodpasture's syndrome detected.
Note: Results evaluated only together with clinical symptoms and other laboratory studies.
