Gliadin Antibody Determination IgA, IgG, ICL
The test detects gliadin antibodies class IgA and IgG, used for diagnosing celiac disease, assessing disease activity, and monitoring gluten-free diet adherence.
Composition (antibodies):
Gliadin IgA — antibodies to gliadin class IgA
Gliadin IgG — antibodies to gliadin class IgG
Biomaterial: Venous blood
- Submit fasting (8-12 hours without food)
- Water intake is allowed
- Avoid alcohol for 24 hours
- Avoid stress and physical exertion 30 minutes before
- suspected celiac disease
- chronic diarrhea or constipation of unknown origin
- weight loss, anemia, or vitamin deficiency
- nutrient absorption disorder
- monitoring gluten-free diet adherence in already diagnosed patients
Mechanism of abnormalities
In celiac disease, the immune system produces antibodies against gluten proteins (gliadin). These antibodies cause small intestine mucosal inflammation, villi damage, and nutrient absorption disorder.
Negative result — gliadin IgA and IgG antibodies not detected
Positive result — gliadin IgA or IgG antibodies detected, indicating celiac disease or increased risk of its development
Important: the result is assessed together with clinical data and other laboratory tests; small intestine biopsy is sometimes required
