IA-2A — anti-tyrosine phosphatase antibodies, quantitative (ICL)
Determines antibodies to tyrosine phosphatase of pancreatic beta-cells. Used for autoimmune diabetes diagnosis and prognosis.
Deviation mechanism: antibodies against tyrosine phosphatase → beta-cell destruction → reduced insulin → elevated glucose.
Biomaterial: Venous blood
- Draw blood fasting (8-12 hours without food)
- Exclude alcohol 24 hours before
- Avoid stress and physical activity 30 minutes before
- Suspected autoimmune diabetes;
- early/atypical disease onset;
- rapidly progressive diabetes requiring insulin;
- diabetes type differential diagnosis.
Negative — anti-tyrosine phosphatase antibodies not detected.
Positive — confirms autoimmune diabetes character.
Endocrinologist consultation recommended.
