ICA — anti-islet cell antibodies, quantitative (ICL)
Detects antibodies to pancreatic islet cells for autoimmune diabetes diagnosis and beta-cell destruction risk assessment.
Deviation mechanism: antibodies against islet cells → beta-cell destruction → reduced insulin → elevated glucose.
Biomaterial: Venous blood
- Draw blood fasting (8-12 hours without food)
- Exclude alcohol 24 hours before
- Avoid stress and physical activity 30 minutes before
- Suspected autoimmune diabetes;
- early/atypical disease onset;
- rapidly progressive diabetes requiring insulin;
- diabetes type differential diagnosis.
Negative — anti-islet cell antibodies not detected.
Positive — confirms autoimmune diabetes character.
Endocrinologist consultation recommended.
