PG I/II — Pepsinogen I/II
Non-invasive assessment of gastric mucous membrane condition. Screening of atrophic gastritis — a precancerous condition. Assessment of gastric cancer development risk at early stages. Used for monitoring mucosa condition in patients with chronic gastritis and after H. pylori treatment. Helps identify hidden pathological changes when dyspepsia symptoms are mild or absent.
What the test evaluates:
- Concentration of pepsinogen I (PG I) and pepsinogen II (PG II) in blood serum
- PG I/PG II ratio — indicator of atrophic gastric mucosa changes (reduced ratio may indicate atrophic gastritis)
- Allows indirect assessment of gastric secretory function and precancerous change risk
Biomaterial: Venous blood
- Draw blood fasting (last meal 8-12 hours before)
- Exclude alcohol 24 hours before
- Limit proton pump inhibitor and antacid intake 24-48 hours before if safe and by physician prescription
- Avoid intense physical activity and stress 24 hours before
Medications:
- Proton pump inhibitors, antacids, and gastroprotectors may affect pepsinogen levels
- Medication discontinuation only by physician prescription
- Inform laboratory and physician of all medications taken
Recommended for:
- Dyspeptic symptoms, chronic gastritis, elevated ulcer risk or atrophic changes
- Patients with family predisposition to gastric cancer
- Patients after H. pylori treatment for mucosa recovery assessment
- Patients with unclear gastric symptoms when endoscopy is difficult or contraindicated
Results evaluated together with clinical data, endoscopic study, and other gastroenterological markers.
Normal: PG I/PG II ratio corresponds to laboratory reference values; gastric mucosa without pronounced atrophy signs; normal secretory function
Deviations:
- reduced PG I/PG II ratio indicates atrophic gastritis;
- elevated gastric cancer risk;
- endoscopy with biopsy may be required for diagnosis confirmation;
- changes more often observed with chronic H. pylori infection, autoimmune gastritis, or prolonged specific drug intake.
