Proinsulin (Proinsulin)
The test determines the level of proinsulin — the insulin precursor synthesized by pancreatic beta-cells. Used to assess beta-cell function, diagnose early diabetes stage, and insulin resistance. Helps detect imbalance between proinsulin and insulin, which may be an early marker of carbohydrate metabolism disorders.
What the test evaluates:
- Proinsulin concentration in blood serum
- Pancreatic beta-cell function
- Proinsulin-to-insulin ratio disorder, which may indicate type 2 diabetes development risk
Biomaterial: Venous blood
- Draw blood fasting
- Still water is permitted
- Exclude intense physical activity, stress, alcohol, sweets, caffeine 24 hours before
Medications:
- Insulin, hypoglycemic drugs, glucocorticoids, hormonal agents may affect results
- Medication discontinuation only by physician agreement
Recommended for:
- Suspected prediabetes, diabetes, or insulin resistance
- Obesity, metabolic disorders, increased fatigue
- PCOS and menstrual irregularities
- Metabolic syndrome and elevated cardiovascular disease risk
Elevated proinsulin: may indicate beta-cell dysfunction, insulin resistance, or early diabetes stage
Normal level: normal insulin and proinsulin secretion and balance
Proinsulin/insulin ratio: important indicator for differentiating insulin resistance from beta-cell secretion disorders.
