Quantitative Determination of IgA Antibodies to Transglutaminase, ICL
The test detects IgA antibodies to tissue transglutaminase, the main celiac disease marker. Used for disease diagnosis, activity assessment, and monitoring gluten-free diet adherence.
Biomaterial: Venous blood
- Submit fasting (8-12 hours without food)
- Avoid alcohol for 24 hours
- Avoid stress and physical exertion 30 minutes before
- If taking immunomodulators, hormonal, or anti-inflammatory medications — inform the doctor.
- suspected celiac disease
- chronic diarrhea or constipation of unknown origin
- weight loss, anemia, vitamin deficiency
- nutrient absorption disorder
- monitoring treatment in patients with established celiac disease
Mechanism of abnormalities
In celiac disease, the immune system produces antibodies against the tissue transglutaminase enzyme located in the small intestine mucosa. This causes inflammation, intestinal villi damage, and nutrient absorption disorder.
Negative result — tTG IgA antibodies not detected.
Positive result — tissue transglutaminase antibodies detected, characteristic of celiac disease or increased risk of its development.
Important: the result is assessed only together with clinical data and other laboratory tests. In some cases, small intestine biopsy is required.
