Renin
The test determines the level of renin — the enzyme-hormone produced by the juxtaglomerular apparatus of the kidneys. Renin plays a key role in blood pressure regulation, water-electrolyte balance, and circulating blood volume. Is an important RAAS component. Used to diagnose arterial hypertension causes and electrolyte metabolism disorders. Applied for primary and secondary hyperaldosteronism differentiation.
What the test evaluates:
- Renin concentration in blood
- RAAS activity
- Blood pressure and electrolyte balance regulation
Biomaterial: Venous blood
- Draw blood fasting
- Discontinue RAAS-affecting drugs 2 weeks before (by physician agreement)
- Exclude physical activity, stress, alcohol 24 hours before
- Body position (sitting/lying) and blood draw time must correspond to physician recommendations
Medications:
- Diuretics, ACE inhibitors, ARBs, beta-blockers, aldosterone antagonists may significantly distort results
- Medication discontinuation only by physician prescription
Recommended for:
- Suspected hyperaldosteronism and adrenal diseases
- Therapy-resistant arterial hypertension
- Kidney diseases and electrolyte disorders
- Persistent hypertension
Elevated renin: secondary hyperaldosteronism; renal hypertension; heart failure; dehydration, diuretic intake
Reduced renin: primary hyperaldosteronism (Conn's syndrome); excess salt intake; some forms of endocrine hypertension
Note: Interpreted together with aldosterone and aldosterone-renin ratio (ARR) calculation.
